Apicella Lab

The University of Texas at San Antonio

Department of Biology

Neurosciences Institute

Welcome!

Microcircuits of the Auditory Cortex

Right: A layer 2/3 fast-spiking interneuron of the auditory cortex. Projections in purple. Surrounding bodies in blue.
Cortical microcircuits process sensory information to drive behavior. Deciphering how populations of neurons encode information, generate perceptions, and execute behavioral decisions requires working at both the cellular and system levels.

Research Interests

The goal of this laboratory is to reveal the neural basis of perception. More specifically, We want to understand exactly how cortical microcircuits process sensory information to drive behavior. To assess how populations of neurons concur to encode information, generate perceptions, and execute behavioral decisions, requires working at both the cellular and system level. Towards this goal, by turning neurons 'ON' and 'OFF' using optogenetic and pharmacogenetic approaches, we can monitor and then manipulate specific subsets of neurons in awake behaving mice. This approach will allow us to quantitatively determine how specific subsets of neurons contribute to sensory processing and behavior. By complementing our in vivo work with synaptic connectivity and network dynamics analysis in vitro, we are going to achieve a more complete understanding for how neural circuits in our brain support sensation, action, and cognition.

News

Lab publishes in the Journal of Neuroscience: Callosal Projections Drive Neuronal-Specific Responses in the Mouse Auditory Cortex. Congratulations Crystal!

Postdoctoral position available, see description under "Open Positions".

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This world is no place of rest, but for effort. Steady, continuous, undeviating effort.


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- Dr. Thomas Dent Mutter

Webpage: Chad Alan Milam
Page Last Updated: 5/12/15